Inhibition of Adhesion, Proliferation, and Invasion of Primary Endometriosis and Endometrial Stromal and Ovarian Carcinoma Cells by a Nonhyaluronan Adhesion Barrier Gel

Table 1

Liquid antiadhesion barriers, characteristics, and overview of published studies [11, 12, 14, 23–25, 27, 50–59] in vitro and in vivo.

Name	Active chemical	Company	Intervention	Study	Outcome	Reference
Hyalobarrier	Hyaluronic acid; cross-linked polysaccharide	Fidia Adv. Biopolymers	Adhesion	Rabbit	Significant adhesion reduction	[50]
			Myoma	Human	Nonsignificant adhesion reduction	[51]
			Adhesion	Rabbit	Significant adhesion reduction	[52]
Hyalobarrier	0.4% hyaluronic acid; cross-linked polysaccharide	Baxter GmbH	Adhesion	Wistar rat	Significant adhesion reduction	[53]
Seprafilm	0.4% hyaluronic acid,; carboxymethyl cellulose	Genzyme Corp.	Colorectal cell line HT29	Nude mice	No significance between controls versus treated nude mice	[24]
			Adhesion	Wistar rat	20% were adhesion-free	[54]
			Ovarian cancer,; retrospective study, colorectal cancer	Human; Human	Significant adhesion reduction; Nonsignificant 1- and 2-year disease-free survival rates, no treatment versus treatment	[14]
			Cancers (ovary, fallopian tube, and peritoneum); retrospective study	Human	Nonsignificant 2.1-year disease-free survival rate, no treatment versus treatment	[27, 49]
Sepracoat	0.4% hyaluronic acid, Na^+-saline	Genzyme Corp.	Colon carcinoma cell line CC-531	In vitro	Inhibited tumor cell adhesion on mesothelial cells	[25]
				Rat	No significant effect on tumor growth	[25]
(Pure substance)	Sodium hyaluronate	Pharmacia	Various colorectal carcinoma cell lines CD44+	Rat	Significantly increased tumor nodules, peritoneal cavity	[23]
				In vitro	Significant tumor cell proliferation and motility induction	[23]
Adept	4% icodextrin; (α1-4-linked dextrin)	Shire GmbH	Adhesion	Wistar rat	Significant adhesion reduction	[53]
			Adhesion	Wistar rat	Adhesion-free incidence 0%	[54]
Oxiplex/AP gel	Polyethylene oxide; carboxymethyl cellulose	FzioMed, Inc.	Adhesion including patients with endometriosis	Human	Marked adhesion reduction	[11]
				Human	Significant adhesion reduction	[12]
Intercoat	Polyethylene oxide, sodium carboxymethyl cellulose	Ethicon, Inc.	Adhesion	Balb/c mice	Significant adhesion reduction	[55]
			Adhesion	Wistar rat	20% were adhesion-free	[54]
			Adhesion	Human	Significant adhesion reduction	[56]
			Adhesion	Human	Not significant	[57]
			Adhesion, proliferation, and; invasion	In vitro: primary Ec-ESC, Eu-ESC, ovarian carcinoma cell lines	Significant reduction of adherence, proliferation, and invasion	This study