Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells

Figure 3

2DG sensitized MCF-7/MDR cells towards DOX. (a) The cytotoxicity of DOX was enhanced with the increase of 2DG concentration. ; versus control group. (b) Cell apoptosis was increased under the combination of 2DG and DOX. (A) The control group; (B) 10 mM 2DG group; (C) 20 mM 2DG group; (D) 30 μM DOX; (E) the combination of 10 mM 2DG and 30 μM DOX; (F) the combination of 20 mM 2DG and 30 μM DOX. (c) The western blot assay was carried out after being exposed to either 2DG (10 mM) or DOX (30 μM) or the combination of 2DG and DOX.

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