Research Article
Identification and Validation of Potential New Biomarkers for Prostate Cancer Diagnosis and Prognosis Using 2D-DIGE and MS
Table 4
Deregulated proteins in prostate cancer identified with 2D-DIGE and MS.
| Spot | | Acc. no. | Protein name | Ratio Tf versus Tu | value (-test) Tf versus Tu | value (-test) Tf versus Tu |
| Down 01 | | P22626 | Heterogeneous nuclear ribonucleoproteins A2/B1 | −21.8 | 0.043 | 0.035 | Down 05 | | P17661 | Desmin | −15.7 | 0.156 | 0.024 | Down 06 | | P17661 | Desmin | −9.1 | 0.085 | 0.009 | Down 04 | | P17661 | Desmin | −3.8 | 0.037 | 0.012 | Down 09 | | P09493 | Tropomyosin alpha-1 chain | −2.9 | 0.035 | 0.042 | Down 10 | | P09493 | Tropomyosin alpha-1 chain | −2.9 | 0.009 | 0.020 | Down 08 | | P09493 | Tropomyosin alpha-1 chain | −2.8 | 0.010 | 0.019 | Down 07 | | P12277 | Creatine kinase B-type | −2.7 | 0.045 | 0.009 | Down 11 | | Q05682 | Caldesmon | −2.2 | 0.115 | 0.026 | Down 02 | | P08670 | Vimentin | −1.7 | 0.053 | 0.024 | Down 03 | | P17661 | Desmin | −1.6 | 0.039 | 0.110 | Up 01 | | COEA1 | Collagen alpha-1(XIV) chain | 2.4 | 0.104 | 0.042 | Up 03 | Mix | ANXA5 | Annexin A5 | 3.7 | 0.038 | 0.033 | | | A1BG | Alpha-1B-glycoprotein | 3.7 | 0.038 | 0.033 | | | P04217 | Alpha-1B-glycoprotein | 3.7 | 0.038 | 0.033 | Up 02 | | TCPA | T-complex protein 1 subunit alpha | 46.7 | 0.405 | 0.049 |
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2D-DIGE: two-dimensional differences in gel electrophoresis; MS: mass spectrometry; Acc. no.: accession number; Tf: tumor free; Tu: tumor; -test: two-sided Mann-Whitney -test; ratio: division of the mean; mean: normalized spot volume.
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