Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells

Figure 4

Expression levels of IFN-β and Noxa following addition of UV-irradiated reovirus in tumor cells. (a), (b) IFN-β and Noxa mRNA levels following the addition of reovirus or UV-reo. Reovirus and UV-reo were added to the cells in equivalent doses for an MOI of 20. Following a 24-hour incubation, cells were harvested for the evaluation of IFN-β and Noxa mRNA levels by qRT-PCR analysis. Data were normalized by the data of reovirus group. The data shown represent the mean ± SD of triplicate measurements. , , and , compared with mock group; , compared with reovirus group.

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