The Effect of Primary Cancer Cell Culture Models on the Results of Drug Chemosensitivity Assays: The Application of Perfusion Microbioreactor System as Cell Culture Vessel

Figure 5

(a) Chemosensitivity evaluations of primary oral cavity cancer cells cultured in various cell culture models and treated with cisplatin at various concentrations; significant difference is expressed by a star (), (b) confocal microscopic observation of cell viability of cancer cells cultured in various cell culture models ((I): 2D culture model; (II): 3D culture model (low cell density); (III): 3D culture model (high cell density); (IV): tumor culture model; (V): spheroid culture model) and treated with cisplatin at the concentration of (i) 0 and (ii) 8 μg/mL; green and red dots represent live and dead cells, respectively.

(a)

(b)