Reference AUC PSA AUC %fPSA AUC % −2 proPSA AUC PHI Relationship of % −2 proPSA and GS Relationship of PHI and GS (95% CI) (95% CI) (95% CI) (95% CI) Catalona et al., 2011 [19 ] ( ) 0.525 0.648 Not reported 0.703 Not reported The probability of GS ≥ 7 was 26.1% when PHI < 25 and 42.1% when PHI ≥ 55 Jansen et al., 2010 [20 ] Rotterdam ( ) 0.585 (0.535–0.634) 0.675 (0.627–0.721) 0.716 (0.669–0.759) 0.750 (0.704–0.791) % −2 proPSA discriminates GS ≥ 7 (with biopsy GS, ; with pathologic GS, ) PHI discriminates GS ≥ 7 (with biopsy GS, : <0.0001; with pathologic GS, ) Innsbruck ( ) 0.543 (0.473–0.594) 0.576 (0.523–0.629) 0.695 (0.644–0.743) 0.709 (0.658–0.756) No (neither with biopsy or with pathologic GS) No (neither with biopsy nor with pathologic GS) Sokoll et al., 2010 [21 ] ( ) 0.58 (0.53–0.64) 0.66 (0.61–0.71) 0.70 (0.65–0.75) 0.76 (0.72–0.81) % −2 proPSA increased with increasing GS ( ) Not reported Lazzeri et al., 2013* [22 ] ( ) 0.50 (0.46–0.54) 0.64 (0.61–0.68) 0.67 (0.64–0.71) 0.67 (0.64–0.71) Significant (Spearman : 0.245; ), and it did improve the prediction of GS ≥ 7 PCa in multivariable accuracy analysis by 7.3% Significant (Spearman : 0.276; ), and it did improve the prediction of GS ≥ 7 PCa in multivariable accuracy analysis by 7.6% Lazzeri et al., 2013** [23 ] ( ) 0.55 (0.47–0.63) 0.60 (0.52–0.68) 0.73 (0.66–0.80) 0.73 (0.66–0.80) Significant (Spearman : 0.366; ), but it did not improve the prediction of GS ≥ 7 PCa in multivariable accuracy analysis Significant (Spearman : 0.464; ), but it did not improve the prediction of GS ≥ 7 PCa in multivariable accuracy analysis Stephan et al., 2013 [24 ] ( ) 0.56 (0.53–0.59) 0.61 (0.59–0.64) 0.72 (0.70–0.75) 0.74 (0.71–0.76) Significantly higher median values of % −2 proPSA were observed for patients with GS ≥ 7 (% −2 proPSA = 2.68) compared with a GS < 7 (% −2 proPSA = 2.34; ) Significantly higher median values of phi were observed for patients with GS ≥ 7 (PHI = 59.7) compared with a GS < 7 (PHI = 53.1; ) Ng et al., 2014 [25 ] ( ) 0.547 (0.421–0.674) 0.572 (0.437–0.708) 0.768 (0.660–0.876) 0.781 (0.675–0.887) Not reported Not reported