Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men

Table 2

Serum probable biomarkers of lipid, apolipoprotein, and oxidative and inflammatory status in participants with different cognitive statuses.

	MMSE scores						Total
	28  ≤  MMSE ≤ 30		24 ≤ MMSE ≤ 27		MMSE ≤ 23
TC (mmol/L)	4.6 (4.0–5.2)	316	4.5 (3.9–5.1)	93	4.8 (4.1–5.5)	31	440	0.273
TG (mmol/L)	1.4 (1.0–1.9)	316	1.3 (1.0–1.8)	93	1.4 (1.1–1.8)	31	440	0.268
HDL-C (mmol/L)	0.95 (0.82–1.12)	316	0.99 (0.88–1.12)	93	1.13 (0.99–1.38)	31	440	0.002
LDL-C (mmol/L)	2.78 (2.32–3.39)	316	2.73 (2.24–3.23)	93	2.89 (1.95–3.49)	31	440	0.793
LPO (μmol/L)	0.70 (0.46–0.98)	298	0.64 (0.47–0.97)	89	0.71 (0.50–0.96)	31	418	0.723
POD (U/mL)	7.81 (5.59–11.41)	304	9.04 (6.42–15.40)	89	9.57 (6.39–13.27)	31	424	0.026
SOD (U/mL)	10.44 (8.79–11.80)	275	10.84 (9.42–12.14)	84	10.73 (9.73–11.71)	29	388	0.134
CAT (U/mL)	51.82 (42.98–59.56)	297	52.25 (43.72–58.05)	84	51.92 (43.36–60.11)	30	411	0.962
GSH-px (μmol/L)	70.91 (59.18–79.87)	288	70.95 (48.07–79.57)	83	67.95 (44.43–82.19)	30	401	0.840
IL-1β	9.0 (8.0–10.0)	301	9.0 (8.0–10.0)	85	9.0 (8.0–9.8)	29	415	0.708
IL-4	8.8 (8.0–9.0)	302	8.0 (8.0–9.0)	89	8.0 (7.5–9.5)	31	422	0.462
IL-6	21.0 (16.0–29.0)	299	26.0 (18.0–38.5)	87	27.0 (19.0–35.0)	29	415	0.001
IL-10	21.0 (17.0–25.5)	299	21.0 (16.3–25.0)	84	20.0 (16.8–23.3)	30	413	0.961
TNF-α	8.0 (7.0–9.0)	302	8.0 (7.0–9.0)	88	8.0 (7.0–9.0)	31	421	0.224
TGF-β	8087.0 (601.0–15318.0)	303	9093.5 (1732.5–14060.8)	88	6455.5 (2442.2–11118.0)	31	422	0.565
RANTES	585.3 (435.5–830.9)	302	589.0 (426.5–870.8)	89	670.5 (457.5–997.0)	31	422	0.699
ApoA1 (mg/mL)	1.14 (0.97–1.28)	289	1.10 (0.97–1.27)	81	1.05 (0.68–1.37)	28	398	0.545
ApoA2 (μg/mL)	292.20 (247.00–358.70)	295	262.30 (199.40–313.70)	85	271.60 (217.7–364.3)	28	408	0.001
ApoB (μg/mL)	60.20 (41.20–76.70)	295	60.20 (35.88–83.05)	93	47.50 (21.21–61.80)	31	419	0.079
ApoC2 (ng/mL)	4.66 ± 0.25	299	4.57 ± 0.27	85	4.58 ± 0.22	28	412	0.005
ApoC3 (ng/mL)	5.17 ± 0.28	298	5.12 ± 0.25	86	5.10 ± 0.32	29	413	0.147
ApoE (μg/mL)	1.74 ± 0.21	305	1.74 ± 0.22	89	1.79 ± 0.18	30	424	0.421
ApoJ (μg/mL)	159.4 (2.56–201.7)	305	161.79 (3.58–199.88)	89	163.40 (131.74–194.13)	30	424	0.682
ApoH (ng/mL)	5.58 ± 0.11	305	5.57 ± 0.15	89	5.62 ± 0.075	31	425	0.204

Statistics details: one-way ANOVA for ApoC2, ApoC3, ApoE, and ApoH; Kruskal-Wallis test for TC, TG, HDL-C, LDL-C, LPO, POD, SOD, CAT, GSH-px, IL-1β, IL-4, IL-6, IL-10, TNF-α, TGF-β, RANTES, ApoA1, ApoA2, ApoB, and ApoJ.
Data of ApoA2, ApoC3, ApoE, and ApoH are presented as mean ± SD; data of TC, TG, HDL-C, LDL-C, LPO, POD, SOD, CAT, GSH-px, IL-1β, IL-4, IL-6, IL-10, TNF-α, TGF-β, RANTES, ApoA1, ApoA2, ApoB, and ApoJ are presented as median (first quartile–third quartile).
Compared to 24 ≤ MMSE ≤ 27, .
Borderline significance.
As the objective concentration was too low, the fluorescence intensity was used as the relative concentration.