Source-Space Cross-Frequency Amplitude-Amplitude Coupling in Tinnitus

Table 2

Summary of analyses for specific frequency windows described by Llinás et al. [11, 12]. denotes the partial correlation between mAAC and group assignment controlling for age. A positive correlation indicates an increase of mAAC in the tinnitus group compared to the controls. is the zero-order correlation between mAAC and age. gives the two-sample statistic for comparing mAAC between tinnitus participants and controls. All effect sizes are measured in terms of Cohen’s ; CI denotes the confidence interval for . The hemispheric comparison is between mAAC in the auditory cortices ipsilateral and contralateral to the tinnitus in subjects with unilateral tinnitus; the statistic is for a pairwise test. All values are computed by means of nonparametric permutation tests.

	Theta window; (4 Hz ≤ f1, f2 ≤ 8 Hz)	Theta-beta/gamma window; (4 Hz ≤ f1 ≤ 8 Hz,; 13 Hz ≤ f2 ≤ 40 Hz)
	−0.048 ()	0.082 ()
Effect size	−0.110 (CI: −0.84, 0.70)	0.188 (CI: −0.47, 0.89)
	0.635 ()	1.808 ()
Effect size	0.189 (CI: −0.48, 0.81)	0.537 (CI: −0.03, 1.10)
	0.264 ()	0.384 ()
Hemispheric comparison	= −0.418 ()	= −0.122 ()