Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 11

DBZ knockdown alters expression of transcription factors involved in OL differentiation. Primary cultures of OPCs were transfected with DBZ-5i or CONT-si 24 h before PDGF and bFGF deprivation to induce differentiation. Total RNA was prepared 24 h after mitogen deprivation. (a, b) The effect of DBZ knockdown on the expression of well-characterized transcription factors was examined using qRT-PCR. (a) Expression of the transcription factor negatively regulating oligodendrocyte differentiation. (b) Expression of the transcription factor positively regulating oligodendrocyte differentiation. ; versus CONT-si (). (a) and (b) are adapted with permission from Shimizu et al. [19].

(a)

(b)