Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 17

Activation of the PDKI-SGKI-NDRG1-adhesion molecule pathway returns to the control level after 3 weeks of recovery. (a) Quantification of the sum of the cross-sectional areas of the oligodendrocytes is measured from transverse electron micrographs of the CC of no-stress controls (18-week-old mice) (Cont) and after 3 weeks of recovery after exposure to WIRS (18-week-old mice) (stress and recover). Morphometric measurements were made using ImageJ software. The results are expressed as the mean ± SEM of 3 independent experiments. , -test. (b) Western blot analysis of the CC of mice exposed to repeated WIRS (15-week-old mice) and after 3 weeks of recovery (18-week-old mice). (c) Effects of a chronic stress, that is, 3 weeks of recovery, on mouse behavior. After 3 weeks of recovery mice (18-week-old mice) were discontinued showing no significant difference in the tail-suspension test compared to the control mice (18-week-old mice). The results are expressed as the mean ± SEM of 3 independent experiments. , -test. (a)–(c) are adapted with permission from Miyata et al. [37].

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