Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 4

Myelination in the CC of DBZ-KO mice is delayed during the postnatal period but recovers by adulthood. (a–d) In situ hybridization analyses of WT and DBZ-KO littermates at P10 (a, c) or adulthood (b, d) with the antisense RNA probes to DBZ (a, b) and Mbp (c, d) mRNA. The number of cells in the CC of DBZ-KO mice expressing Mbp mRNA was significantly reduced at P10 compared with age-matched WT mice, but it was recovered to WT levels by adulthood. Cg: cingulate gyrus, Mo: motor area. (e, f) Electron microscopic analyses of the CC in P10 (e) or adult (f). (g) Western blot analyses of MBP protein in the CC of WT or DBZ-KO mice at P10 or adulthood. (h) Scatter plot of -ratio values in the CC of WT or DBZ-KO mice at adulthood. Four hundred and four axons from four animals were analyzed for each group. Scale bar: (a–d) 50 μm, (e, f) 5 μm. (a)–(h) are adapted with permission from Shimizu et al. [19].

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