Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 5

Immature oligodendrocytes are increased in DBZ-KO mouse. (a, b) Immunohistochemistry with antibodies against PDGFRα and CC1 on the CC sections from WT and DBZ-KO littermates at P10 or adult. Quantification of the proportion of PDGFRα+ and CC1+ cells at P10 (a) and adulthood (b). (c) Chromatin density was calculated as the ratio of electron dense chromatin area to the cell nucleus area using ImageJ software. One hundred and forty oligodendrocytes from four animals were analyzed for each group. by Student’s -test following two-way-ANOVA. (a)–(c) are adapted with permission from Shimizu et al. [19].

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