Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder

Figure 8

Effect of DBZ knockdown on oligodendrocytes cell morphology. Morphological features of primary cultured oligodendrocytes treated with CONT-si or DBZ-5i as determined by light microscopy (a, b) or electron microscopy (c–k). Micrographs of CONT-si-treated oligodendrocytes (a, c–g) or DBZ-5i-treated oligodendrocytes (b, h–k). CONT-si-treated oligodendrocytes had morphological characteristics of Type 2 or Type 3 cells corresponding to immature oligodendrocytes or mature oligodendrocytes, respectively, whereas DBZ-5i-treated oligodendrocytes were largely characterized by Type 1 corresponding to OPCs. Scale bar: (a, b) 50 μm, (c) 10 μm, (d, f, g, h) 5 μm, (e) 0.1 μm, (i, j) 1 μm, (k) 0.1 μm. (a)–(k) are adapted with permission from Shimizu et al. [19].

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