Aberrant Functional Connectivity Architecture in Alzheimer’s Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis

Figure 2

Mean absolute -score matrices for normal control (a), MCI (b), and AD (c). Each figure shows a 90 × 90 square matrix, in which each entry indicates the mean functional connectivity strength between the corresponding pair of brain regions. The diagonal running from the lower right to the upper left is intentionally set in black. The -score of the functional connectivity is indicated with a colored bar. The lower row indicates the regions that exhibit visual differences between the normal control and MCI (d), MCI and AD (e), and normal control and AD groups (f), which were calculated using the functional connectivity strengths of the former minus the latter.

(a) NC

(b) MCI

(c) AD

(d) NC-MCI

(e) MCI-AD

(f) NC-AD