Aberrant Functional Connectivity Architecture in Alzheimer’s Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis

Figure 4

The correlation between the MMSE scores and the functional connectivity strengths. The upper line denotes the functional connectivities significantly correlated with the MMSE scores in the MCI (a), AD (b), and combined MCI and AD (c) groups. The blue color represents the functional connectivity that is positively correlated with the MMSE scores, and the red color represents the functional connectivity that is negatively correlated with the MMSE scores. The lower line denotes the correlation between the MMSE scores and the functional connectivity strength (e.g., between the right medial superior frontal gyrus (SFGmed) and the posterior cingulate gyrus (PCC)) in the MCI (d), AD (e), and combined AD and MCI (f) groups. For details, please refer to Table S3.

(a) MCI

(b) AD

(c) MCI and AD

(d) MCI

(e) AD

(f) MCI and AD