Biological and Pharmacological Aspects of the NK1-Receptor

Figure 2

Heterotrimeric G protein activation by GTP and consequent separation of subunits. Heterotrimeric G proteins have been grouped into four distinct families based on the amino acid homologous sequence: , , , and G_12/13. There are two major signaling pathways associated with and subunits and are mainly how NK-1 receptor signals [48, 50, 59]. The different signaling pathways activated by each subunit will be explained below. This figure was made using Servier Medical Art collection (http://creativecommons.org/licenses/by/3.0).