BioMed Research International

Research Article

RC-3095, a Selective Gastrin-Releasing Peptide Receptor Antagonist, Does Not Protect the Lungs in an Experimental Model of Lung Ischemia-Reperfusion Injury

Table 1

Hemodynamic variables and gas exchange. Comparative analysis of the groups regarding the time during all experimental protocol.
 MAPPaO2P PaCO2
 Baselinet2FinalBaselinet2FinalBaselinet2Final
SHAM94
90; 140		90  
75; 103		86 
73.5; 90		0.165342.2 
265.2; 353.9		278.6 
231.4; 300.5		300.6 
255.95; 378.15		0.36847.4 
44.6; 49.9		44.9 
43.7; 48.9		47.5 
45.45; 50.8		0.779
IR110* 
96; 151		81 
73; 90		65** 
64; 75		0.007187.1 
148.6; 318.4		228.1 
171.9; 348		149.1 
147.4; 161.2		0.44935.9 
32.5; 44.9		39.9 
34.1; 44.4		20.7 
20.5; 49.7		0.819
RC-PRE93*  
85.5; 125		67.5 
62; 73		46** 
45; 53		0.015282.3 
251.2; 341.7		223.7 
204.4; 394.4		116.5 
88.7; 269.3		0.07441.2 
37.9; 44		36.7 
34.1; 37		46.4 
38.4; 50.8		0.091
RC-POST 86.5  
80.3; 117.3		76 
72.5; 77		61.5 
51; 73		0.105289.05 
268.5; 294.4		208.1 
194; 218.9		181.6 
103.75; 229.5		0.05047.5 
40.9; 49.8		52.3 
50.7; 66.85		51.25 
49.75; 69.9		0.174
General 94*# 
85.5; 140		76** 
68; 90		65## 
50; 75		<0.001288.2* 
199.2; 324.6		228.1 
199.2; 324.6		195.3** 
129.4; 271.9		0.00544.6 
36.6; 49.4		43.7 
36.7; 43.7		48.7 
33.9; 51.5		0.801
The values are described as median ± interquartile range. SHAM group did not have reperfusion and was observed for 120 minutes. t2: five minutes after reperfusion. Final: 120 minutes after reperfusion. The same symbols represent statistically significant difference. MAP = mean arterial pressure; PaO2 = partial pressure of arterial oxygen; PaCO2 = partial pressure of arterial carbon dioxide. ≤ 0.05.