RC-3095, a Selective Gastrin-Releasing Peptide Receptor Antagonist, Does Not Protect the Lungs in an Experimental Model of Lung Ischemia-Reperfusion Injury
Table 1
Hemodynamic variables and gas exchange. Comparative analysis of the groups regarding the time during all experimental protocol.
MAP
PaO2
P
PaCO2
Baseline
t2
Final
Baseline
t2
Final
Baseline
t2
Final
SHAM
94 90; 140
90 75; 103
86 73.5; 90
0.165
342.2 265.2; 353.9
278.6 231.4; 300.5
300.6 255.95; 378.15
0.368
47.4 44.6; 49.9
44.9 43.7; 48.9
47.5 45.45; 50.8
0.779
IR
110* 96; 151
81 73; 90
65** 64; 75
0.007
187.1 148.6; 318.4
228.1 171.9; 348
149.1 147.4; 161.2
0.449
35.9 32.5; 44.9
39.9 34.1; 44.4
20.7 20.5; 49.7
0.819
RC-PRE
93* 85.5; 125
67.5 62; 73
46** 45; 53
0.015
282.3 251.2; 341.7
223.7 204.4; 394.4
116.5 88.7; 269.3
0.074
41.2 37.9; 44
36.7 34.1; 37
46.4 38.4; 50.8
0.091
RC-POST
86.5 80.3; 117.3
76 72.5; 77
61.5 51; 73
0.105
289.05 268.5; 294.4
208.1 194; 218.9
181.6 103.75; 229.5
0.050
47.5 40.9; 49.8
52.3 50.7; 66.85
51.25 49.75; 69.9
0.174
General
94*# 85.5; 140
76** 68; 90
65## 50; 75
<0.001
288.2* 199.2; 324.6
228.1 199.2; 324.6
195.3** 129.4; 271.9
0.005
44.6 36.6; 49.4
43.7 36.7; 43.7
48.7 33.9; 51.5
0.801
The values are described as median ± interquartile range. SHAM group did not have reperfusion and was observed for 120 minutes. t2: five minutes after reperfusion. Final: 120 minutes after reperfusion. The same symbols represent statistically significant difference. MAP = mean arterial pressure; PaO2 = partial pressure of arterial oxygen; PaCO2 = partial pressure of arterial carbon dioxide. ≤ 0.05.