Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice

Figure 1

DRD2 expression increases and D2-like receptor agonist quinpirole downregulates Th17-related cytokine expression but upregulates Treg-related cytokine expression in lymphocytes in CIA mice. Lymphocytes from spleens of CIA mice (at day 41 after primary immunization) were exposed to quinpirole in the presence of Con A for 48 h. Proteins were extracted and Western blot analysis was performed. (a) DRD1 and DRD2 expression in Con A-activated lymphocytes. (b) Left panel shows representative bands and right panel is a statistical graph. Quin: quinpirole; versus intact; versus CIA.

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