Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case

Figure 3

MiRNA-mRNA functional regulatory network of RB DEL specific MFRM 1680-1 and functions of miRNAs and mRNAs. (a) Significant biological pathways that genes of MFRM 1680-1 identified by multiobjective GA participated in. The -axis represents transformation of value. (b) miRNA-mRNA functional regulatory network of RB DEL specific MFRM 1680-1. Six miRNAs and 52 genes were involved in the network. miRNA and mRNA were connected with an edge if and only if the mRNA was targeted by the miRNA and there was a significant negative correlation between miRNA and mRNA expression. The miRNAs in red color were previously reported to play key roles in the pathogenesis of MM. (c) Significant biological pathways that genes of miRNA-mRNA functional regulatory network of RB DEL specific MFRM 1680-1 participated in. The -axis represents transformation of value.

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