Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case

Figure 5

Hierarchical clustering diagrams. (a) The clustering diagram on t(14;16) and t(4;14) samples using the miRNAs and mRNAs in MFRM 1649-2. (b) The clustering diagram on RB DEL and t(11;14) samples using the miRNAs and mRNAs in MFRM 1653-3. (c) The clustering diagram on RB DEL, t(11;14) and t(14;16) samples using the miRNAs and mRNAs in MFRM 1962-4. Clustering could separate t(14;16) samples from other two subtypes. The samples in red color were from respective MFRMs. Although the MFRMs were identified in small subsets of samples only, they captured the principle characteristics of different MM subtypes.

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