Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease

Figure 4

Dynamic patterns of AIR progression related to various initial levels of indicators and adjustable system parameters. -axis represents time (in hours) and -axis represents number of indicators (pathogen, dead hepatocyte, activated neutrophil, activated monocyte, TNF-α, HMGB-1, and IL-10) during AIR progression. (a) Combined dynamic patterns of indicators represent a Healing Process in AIR progression (pathogen initial counts = 100). (b) Combined dynamic patterns of indicators represent a Persistent Infection in AIR progression (pathogen initial counts = 10000). (c) Combined dynamic patterns of indicators represent Organ Dysfunction in AIR progression (pathogen initial counts = 100000).