Research Article
Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease
Table 1
Definition of parameters and experimental values in Kupffer Cell local response model.
| Parameters | Description | Value | References |
| | Salmonella growth rate | 1.2–3.6/h | [20] | | Salmonella carrying capacity | cells/g liver | [32] | | Rate at which pathogens are killed by Kupffer Cells | 0.03/per Kupffer Cell/h | [31] | | The extent of ligands binding to receptors (not specified) | 2 | Estimated | | Concentration of Kupffer Cells which phagocytose half of Salmonella | 0.03 | [31] | | Proliferation rate of Kupffer Cells under inflammation | 0.015–2/h | Estimated | | Kupffer Cell carrying capacity in liver | | [40] | | Unbinding rate of binding Kupffer Cells | 0.1–0.77/h | [33] | | Killing rate of free Kupffer Cells induced by binding to pathogens | 0.23–0.9/h | [33] |
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