Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease

Table 2

Definition of parameters and experimental values in neutrophil immune response model.

Parameters	Description	Value	References
	Rate at which pathogens are killed by neutrophils	20–100/per neutrophil/h	[41]
	The maximum number of TNF-α being released by Kupffer Cells per enzyme molecule per hour	10/h	Estimated
	The maximum number of TNF- being released by activated neutrophils per enzyme molecule per hour	1000/h	Estimated
	Number of Kupffer Cells at which the reaction rate is half of maximum production rate	10000 cells	Estimated
	Number of activated neutrophils at which the reaction rate is half of maximum production rate	10000 cells	Estimated
	Concentration of neutrophils which phagocytose half of Salmonella		[42]
	Degradation rate of TNF-α	0.025–0.5/h; (measured in kidney)	[43]
	Influx rate of neutrophils into blood vessel	0.1–0.72/h	[44]
	Resting neutrophil carrying capacity in blood vessel	cells	[22]
	Apoptotic rate of resting neutrophils per hour	0.069–0.12/h	[45]
	Apoptotic rate of activated neutrophils per hour	0.05/h	[45]
	Unbinding rate of activated neutrophils per hour	0.01–0.5/h	Estimated
	Auxiliary parameter associated with the activation rate of resting neutrophils	3/h	Estimated
	Degradation rate of parameter to maintain a slow-saturation curve	0.003/h	Estimated