Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease

Table 4

Definition of parameters and experimental values in monocyte immune response model.

Parameters	Description	Value	References
	Influx rate of monocytes into blood vessel	0.5/h	[44]
	Rate at which pathogens are killed by inflammatory monocytes	7/per monocyte/h	[47]
	Influx rate of monocytes in liver	80/h	[48]
	Resting monocyte carrying capacity in blood vessel	50000 cells	[49]
	Apoptotic rate of resting monocytes per hour	0.2/h	Estimated
	Apoptotic rate of activated monocytes (monocytes-derived-macrophage) per hour	0.08/h	[50]
	The maximum number of HMGB-1 being released by monocytes per enzyme molecule per hour	0.001/h	Estimated
	Number of monocytes at which the reaction rate is half of maximum production rate	10000 cells	Estimated
	Concentration of monocytes which phagocytose half of Salmonella		[47]
	Unbinding rate of binding activated monocytes	0.4/h	[51]
	Degradation rate of HMGB-1	0.5–3/h	Estimated
	Rate at which activated neutrophils are killed by inflammatory monocytes	200/monocyte/h	Estimated