CF750-A33scFv-Fc-Based Optical Imaging of Subcutaneous and Orthotopic Xenografts of GPA33-Positive Colorectal Cancer in Mice

Figure 7

The ¹³¹I-A33scFv-Fc uptake ratio of tumor to normal tissues at different time points. Mice () bearing subcutaneous LS174T tumor xenografts were intravenously injected with ¹³¹I-A33scFv-Fc (185 kBq/g body weight) and then sacrificed at 0.08, 0.5, 2, 5, 8, and 24 h after injection, respectively. The radioactivity of the organ/tissue was counted, and the ratios of tumor-to-blood, tumor-to-small intestine, tumor-to-colon, and tumor-to-muscle were calculated.