Molecular Imaging-Guided Interventional Hyperthermia in Treatment of Breast Cancer

Figure 2

(a) Gradient echo transversal MR images collected prior to injection and at various time points after injection of 3.0 mM ProCA1-affi342-m which is PEGylated ProCA1-affi342 targeting to HER2 in HEPES saline tail vein. The MRI signal on the positive tumor (SKOV-3, right) exhibits significant enhancement at 24 h after injection. Blocking results confirm the specific binding of ProCA1-affi342 to HER2-positive tumors. (b) Enhancement changes of MRI intensity in tumors and at 24 h after injection; highest enhancement was observed. (c) MR imaging of contrast agent ProCA1-affi1907 targeting to EGFR specifically. (d) Immunostaining shows that HER2 targeted ProCA1-affi342 has better tumor penetration than HER2 antibodies. Reprinted, with permission, from [38].

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