Frequency-Dependent Amplitude Alterations of Resting-State Spontaneous Fluctuations in Late-Onset Depression

Figure 1

Maps of the main effect of disease between LOD and NC groups. The ALFF of primary effect of disease was widely distributed over left cerebellum anterior lobe, left cerebellum posterior lobe, left middle orbitofrontal gyrus, left superior occipital, and right superior parietal. (a) Cluster 1 mainly includes left cerebellum anterior lobe; (b) cluster 2 includes left cerebellum posterior lobe; (c) cluster 3 includes left middle orbitofrontal gyrus; (d) cluster 4 mainly includes left superior occipital gyrus and left precuneus; (e) cluster 5 mainly includes right superior parietal gyrus and right precuneus. (f) The interaction of disease and frequency was distributed over right superior frontal gyrus. A single voxel threshold of the map resulting from the -test was set at a , and a minimum cluster size of 2079 mm³ was used to correct by Monte Carlo simulation.

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