Association of Polymorphisms in X-Ray Repair Cross Complementing 1 Gene and Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population

Table 3

Association of XRCC1 genotypes with esophageal cancer.

Genotypes	Case; N (%)	Control; N (%)		OR (95% CI)		OR (95% CI)^*	^*
Codon 194
CC	166 (46.6)	187 (44.6)	Reference	1.00	—	—	—
TC	159 (44.7)	193 (46.1)	0.24	0.93 (0.69, 1.25)	0.62	0.91 (0.66, 1.26)	0.57
TT	31 (8.7)	39 (9.3)	0.18	0.90 (0.53, 1.50)	0.67	0.96 (0.55, 1.68)	0.90
CC + TC	190 (53.4)	232 (55.4)	0.31	0.92 (0.69, 1.23)	0.58	0.92 (0.68, 1.25)	0.59
C	567 (67.7)	491 (69.0)	Reference	1.00	—	—	—
T	271 (32.3)	221 (31.0)	0.30	1.06 (0.86, 1.32)	0.58	0.90 (0.76, 1.21)	0.70
Codon 399
GG	184 (48.5)	223 (51.6)	Reference	1.00	—	—	—
GA	166 (43.8)	169 (40.7)	1.39	1.19 (0.89, 1.59)	0.24	1.14 (0.84, 1.57)	0.40
AA	29 (7.7)	30 (7.7)	0.32	1.17 (0.68, 2.02)	0.57	1.03 (0.57, 1.86)	0.92
GA + AA	195 (51.5)	199 (47.2)	1.47	1.47 (0.22, 1.57)	0.22	1.13 (0.83, 1.52)	0.44
G	534 (70.4)	615 (72.9)	Reference	1.00	—	—	—
A	224 (29.6)	229 (27.1)	1.15	1.13 (0.91, 1.40)	0.28	1.07 (0.85, 1.35)	0.57
−77T>C
TT	310 (83.6)	319 (77.2)	Reference	1.00	—	—	—
TC	59 (15.9)	92 (22.3)	5.09	0.66 (0.46, 0.95)	0.02	0.70 (0.48, 1.03)	0.07
CC	2 (0.5)	2 (0.5)	0.22	1.03 (0.14, 7.35)	0.64	0	1.0
TC + CC	61 (16.4)	94 (22.8)	4.92	0.67 (0.47, 0.96)	0.03	0.69 (0.47, 1.01)	0.06
T	679 (91.5)	730 (88.4)	Reference	1.00	—	—	—
C	63 (8.5)	96 (11.6)	4.37	0.70 (0.50, 0.98)	0.04	0.70 (0.48, 1.00)	0.05

adjusted for age, gender, smoking, drinking, and family history of cancer.