Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population

Table 2

The comparison of the 4 SNPs between the cases and controls.

Group	Genotype (frequency) rs1278279
	G (%)	A (%)	GG	GA + AA	GG + GA	AA	GG	AA
Control	76.5	23.5	121	79	185	15	121	15
Case	75.0	25.0	92	72	154	10	92	10
OR^a	/	1.06	/	1.17	/	0.83	/	0.88
95% CI^a		0.87 to 1.34	/	0.79 to 1.81	/	0.35 to 1.84	/	0.36 to 2.03
	/	n.s	/	n.s	/	n.s	/	n.s
Group	Genotype (frequency) rs3740199
	G (%)	C (%)	GG	GC + CC	GG + GC	CC	GG	CC
Control	51.0	49.0	51	149	153	47	51	47
Case	52.4	47.6	44	120	128	36	44	36
OR^a	/	0.93	/	0.92	/	0.90	/	0.87
95% CI^a		0.76 to 1.14	/	0.58 to 1.49	/	0.54 to 1.52	/	0.48 to 1.61
	/	n.s	/	n.s	/	n.s	/	n.s
Group	Genotype (frequency) rs1871054
	T (%)	C (%)	TT	TC + CC	TT + TC	CC	TT	CC
Control	50.8	49.2	52	148	151	49	52	49
Case	35.7	64.3	29	135	88	76	29	76
OR^a	/	1.84	/	1.64	/	2.65	/	2.78
95% CI^a	/	1.57 to 2.23	/	1.01 to 2.74	/	1.72 to 4.14	/	1.56 to 4.95
	/	<0.0001	/	0.0348	/	<0.0001	/	0.0012
Group	Genotype (frequency) rs1044122
	T (%)	C (%)	TT	TC + CC	TT + TC	CC	TT	CC
Control	56.3	43.7	62	138	163	37	62	37
Case	57.9	42.1	51	113	139	25	51	25
OR^a	/	0.94	/	0.98	/	0.76	/	0.83
95% CI^a		0.73 to 1.12	/	0.64 to 1.57	/	0.44 to 1.39	/	0.44 to 1.53
	/	n.s	/	n.s	/	n.s	/	n.s

ORs and 95% CIs were estimated using logistic regression analyses and adjusted for age, gender, and BMI.