Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis

Table 2

Statistical comparisons between depressed and nondepressed patients.

	Depressed; Mean ± Std. dev	Nondepressed; Mean ± Std. dev	One-tailed; Student’s -test
Clinical features
EDSS	2.9 ± 1.6	2.0 ± 1.2	t = 2.37, P = 0.02
Dd	8.8 ± 5.6	5.0 ± 4.6	t = 2.65, P = 0.01
NBV	1470.8 ± 53.6	1500.8 ± 45.8	t = −2.16, P = 0.02
NCV	526.9 ± 33.5	547.5 ± 28.7	t = −2.37, P = 0.01
FSS	25.3 ± 17.4	17.1 ± 13.9	t = 1.86, P = 0.02
Neuropsychological assessment
SRT-LTS	32.4 ± 14.5	38.1 ± 11.8	= −1.54, = 0.06
SRT-CLTR	20.9 ± 12.9	31.1 ± 12.7	t = −2.94, P < 0.01
SPART	12.9 ± 3.7	16.9 ± 4.4	t = −3.64, P < 0.001
SDMT	35.5 ± 14.8	47.8 ± 12.8	t = −3.21, P < 0.01
PASAT-3	25.7 ± 10.3	38.1 ± 10.0	t = −4.47, P < 0.001
PASAT-2	21.1 ± 8.2	29.4 ± 7.8	t = −3.79, P < 0.001
SRT-D	6.9 ± 2.8	7.4 ± 2.3	= −0.53, = 0.30
SPART-D	5.0 ± 1.8	6.1 ± 2.1	t = −2.08, P = 0.02
WLG	20.0 ± 4.9	20.8 ± 6.2	= −0.57, = 0.29

EDSS, Expanded Disability Severity Scale; Dd, disease duration; NBV, normalized brain volume; NCV, cortical normalized volume; FSS, Fatigue Severity Scale; SRT-LTS, selective reminding test-long term storage; SRT-CLTR, selective reminding test-consistent long term retrieval; SPART, 10/36 spatial recall test; SDMT, symbol digit modalities test; PASAT, paced auditory serial addition test; SRT-D, delayed recall of the selective reminding test; SPART-D, delayed recall of the 10/36 spatial recall test; WLG, word list generation.
Statistically significant differences are in bold.