An Improved Opposition-Based Learning Particle Swarm Optimization for the Detection of SNP-SNP Interactions

Table 2

Detected SNP-SNP interactions associated with AMD. values of detected SNP-SNP interactions before Bonferroni correction, as well as their linkage disequilibrium (LD) correlation coefficients , are also recorded. The SNPs in different SNP-SNP interactions have low LD.

SNP	Gene	Chromosome	Times	Mutual information value		value	LD ()
				Individual	Interaction
rs380390	CFH	1	1	0.1412	0.2955		0.0089
rs1374431	N/A	2		0.0198
rs380390	CFH	1	2	0.1412	0.2949		0.0015
rs2402053	N/A	7		0.0476
rs1329428	CFH	1	2	0.1218	0.2853		0.0019
rs9328536	MED27	9		0.0563
rs380390	CFH	1	2	0.1412	0.2777		0.0050
rs10512174	ISCA1	9		0.0844
rs380390	CFH	1	2	0.1412	0.2775		0.0018
rs718263	NCALD	8		0.0471
rs380390	CFH	1	1	0.1412	0.2760		0.0019
rs223607	N/A	6		0.0079
rs380390	CFH	1	8	0.1412	0.2752		0.0031
rs1363688	N/A	5		0.0949
rs380390	CFH	1	1	0.1412	0.2678		0.0013
rs210758	N/A	4		0.0131
rs380390	CFH	1	1	0.1412	0.2641		0.0040
rs10507949	N/A	13		0.0948