Interleukin-1 β Modulates Melatonin Secretion in Ovine Pineal Gland: Ex Vivo Study

Figure 3

The effects of norepinephrine (NE, 10 μM), interleukin- (IL-) 1β (75 pg/mL), and mixture of NE with IL-1β on hydroxyindole-O-methyltransferase (HIOMT) relative gene (a) and protein (b) expression in the pineal gland explants collected from saline- and lipopolysaccharide- (LPS-) treated ewes. Different lowercase letters indicate significant () differences within the saline-treated group; different capital letters indicate differences within the LPS-treated group; asterisk designates a significant () difference between the saline- and LPS-treated groups; control: no NE/IL-1β treatment.

(a)

(b)