Functional Roles of Calreticulin in Cancer Biology

Figure 1

The protein structure and putative functions of calreticulin domains. The figure represents a schema of calreticulin. The protein contains three functional domains: N-domain, P-domain, and C-domain. There is a signal sequence at N-terminal and a KDEL ER retrieval peptide at C-terminal. The two sets of repeated regions are indicated by triangles and squares, respectively. The putative functions of each domain as shown.