Effects of Dantrolene on Arrhythmogenicity in Isolated Regional Ischemia-Reperfusion Rabbit Hearts with or without Pacing-Induced Heart Failure
Table 2
Electrophysiological effects of dantrolene in non-IR and IR zones in HF and non-HF groups.
(cm/s)
(cm/s)
(cm/s)
(cm/s)
(ms)
(ms)
(ms)
(Hz)
Cai decay () (ms)
APDR slope
HF ()
Baseline
Non-IR
76 ± 11
72 ± 12
66 ± 11
57 ± 7
155 ± 13
130 ± 11
109 ± 10
14.4 ± 1.6
67 ± 11
1.14 ± 0.16
IR
70 ± 9
65 ± 9
60 ± 9
55 ± 9
158 ± 18
130 ± 11
108 ± 11
14.0 ± 1.3
70 ± 14
1.13 ± 0.20
Dantrolene
Non-IR
73 ± 9
66 ± 10
61 ± 9
51 ± 6
167 ± 19
135 ± 11
110 ± 6
11.7 ± 1.2
72 ± 10
1.34 ± 0.25
IR
67 ± 8
61 ± 10
54 ± 9
45 ± 6*
168 ± 22
134 ± 12
109 ± 8
10.9 ± 1.8*
73 ± 10
1.35 ± 0.26
Non-HF ()
Baseline
Non-IR
84 ± 6
79 ± 7
73 ± 5
69 ± 5
148 ± 9
125 ± 9
107 ± 11
13.7 ± 1.3
63 ± 6
1.02 ± 0.16
IR
78 ± 7
73 ± 9
67 ± 7
63 ± 7
149 ± 9
125 ± 9
108 ± 12
12.3 ± 2.2*
69 ± 8*
0.91 ± 0.20
Dantrolene
Non-IR
78 ± 8
70 ± 8
66 ± 7
60 ± 8
162 ± 15
134 ± 11
113 ± 12
11.1 ± 1.5
65 ± 7
1.29 ± 0.38
IR
67 ± 11*
60 ± 9*
52 ± 10*
48 ± 9*
162 ± 15
134 ± 11
111 ± 11
9.7 ± 1.7*
70 ± 9*
1.09 ± 0.25
Values are mean ± SD. , , and , action potential duration at pacing cycle lengths of 300, 200, and 150ms; , , , and , conduction velocity at pacing cycle lengths of 300, 200, 150, and 120ms; : the maximal dominant frequency of ventricular fibrillation; Cai: intracellular ; CV: conduction velocity. Asterisks denote values significantly different between non-IR and IR zones.
