The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican
Mestizo Population
Table 3
Distribution of LEP G-2548A and LEPR Gln223Arg polymorphisms in Mexican Mestizo population.
Study group
Genotype (%)
Phenotype (%)
Allele (%)
LEP G-2548A
G/G
G/A
A/A
A+
G
A
Normal range (BMI 18.5–24.9 kg/m2)
48 (31.2)
78 (50.6)
28 (18.2)
106 (68.8)
174 (56)
134 (44)
Overweight (BMI 25.0–29.9 kg/m2)
52 (35.6)
72 (49.3)
22 (15.1)
94 (64.4)
176 (60)
116 (40)
Obese (BMI ≥ 30 kg/m2)
21 (25.6)
47 (57.3)
14 (17.1)
61 (74.4)
89 (54)
75 (46)
NS
NS
NS
BMI ≥ 25 kg/m2
73 (32)
119 (52.2)
36 (15.8)
155 (68)
265 (58)
191 (42)
NS
NS
NS
LEPR Gln223Arg
Gln/Gln
Gln/Arg
Arg/Arg
Arg+
Gln
Arg
Normal range (BMI 18.5–24.9 kg/m2)
52 (33.8)
65 (42.2)
37 (24)
102 (66.2)
169 (55)
139 (45)
Overweight (BMI 25–29.9 kg/m2)
37 (25.3)
84 (57.6)
25 (17.1)
109 (74.7)
158 (54)
134 (46)
Obese (BMI ≥ 30 kg/m2)
15 (18.3)
50 (61)
17 (20.7)
67 (81.7)
80 (49)
84 (51)
P
NS
BMI ≥ 25 kg/m2
52 (22.8)
134 (58.8)
42 (18.4)
176 (77.2)
238 (52)
218 (48)
NS
; NS: nonsignificance; A+: G/A plus A/A; A−: G/G; Arg+: Gln/Arg plus Arg/Arg; Arg−: Gln/Gln; categorical variables were analyzed using or Fisher exact test, accordingly. Normal range, overweight, and obese by genotype; normal range, overweight, and obese by phenotype; normal range and BMI ≥ 25 kg/m2 by genotype; normal range and BMI ≥ 25 kg/m2 by phenotype.
