Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

Table 1

Eicosanoid compounds as targets for drug development to control diabetes progression.

Drug	Target	Condition	Consideration	Reference
Celecoxibe	COX-2 inhibitor	Diabetes nephropathy	Female patients received higher dose of PGs vasodilator to maintain blood vessel function than male patients.	[74]
Aspirin	Nonselective; COX inhibitor	Diabetes retinopathy	Delay in development of retinal microaneurysms in DR.	[75]
Celecoxibe	COX-2 inhibitor	Diabetes retinopathy	Reduction of vascular leakage.	[76]
Latanoprost	PGF2; agonist	Diabetes retinopathy	Reduces the diameter of dilated retinal arterioles.	[77]
Ketorolac tromethamine	Nonselective; COX inhibitor	Diabetes retinopathy	Patients with suspected or visible fibrovascular proliferation demonstrated a reduction in IL-8 and platelet-derived growth factor levels in vitreous humor.	[78]