Nonalcoholic Steatohepatitis: A Search for Factual Animal Models

Figure 1

The representative photomicrographs present the progression of the histopathological alterations found in the spectrum of nonalcoholic fatty liver disease (NAFLD): (a)/(b) normal liver: no evidence of steatosis, inflammation, or fibrosis; (c)/(d) liver steatosis: moderate steatosis (34–66%), no evidence of inflammation or fibrosis; (d)/(e) nonalcoholic steatohepatitis (NASH): moderate steatosis (34–66%), mild inflammation, and moderate fibrosis with a fibrous septa (FS); (f)/(g) liver cirrhosis secondary to NASH: moderate steatosis (34–66%), moderate inflammation, and severe fibrosis with a regenerative nodule (RN) (Hematoxylin & Eosin and Masson Trichrome staining, ×200). The black, red, and yellow arrows show steatosis, fibrosis, and inflammation, respectively.

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