Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells: Evidence for Further Maturation In Vivo

Figure 4

Histology of IPC-bearing kidneys harvested from mice 4 weeks after transplantation. (a) Hematoxylin and eosin staining revealed the implanted cells beneath the renal capsule. (b) Positive immunofluorescence staining for insulin (green) and c-peptide (red). Electronic merging (yellow) reveals the coexpression of insulin and c-peptide in some cells. (c) Positive immunofluorescence staining for insulin (green) and GCG (red). Electronic merging reveals that these two hormones are localized to distinct cell populations. (d) Positive immunofluorescence staining for insulin (green) and SST (red). Electronic merging reveals that these two hormones are localized to distinct cell populations.

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