Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer

Table 1

Baseline characteristics of the eligible studies for the relationship between functional COX-2 gene polymorphisms and susceptibility to oral cancer.

First author	Year	Country	Ethnicity	Disease	Genotyping method	SNP
Campa [21]	2007	France	Caucasians	OSCC	TaqMan assay	+837 T > C (rs5275)
Chiang-a [22]	2008	Taiwan, China	Asians	OSCC	PCR-RFLP	1195 A > G (rs689466)
Chiang-b [22]	2008	Taiwan, China	Asians	OSCC	PCR-RFLP	−765 G > C (rs20417)
Lin [23]	2008	Taiwan, China	Asians	OSCC	PCR-RFLP	−765 G > C (rs20417)
Pu-a [26]	2009	USA	Caucasians	OPL	TaqMan assay	−765 G > C (rs20417)
Pu-b [26]	2009	USA	Caucasians	OPL	TaqMan assay	+837 T > C (rs5275)
Mittal-a [7]	2010	India	Asians	OSCC	PCR-RFLP	1195 A > G (rs689466)
Mittal-b [7]	2010	India	Asians	OSCC	PCR-RFLP	−765 G > C (rs20417)
Mittal-c [7]	2010	India	Asians	OSCC	PCR-RFLP	+837 T > C (rs5275)
Niu [24]	2011	China	Asians	OSCC	PCR-RFLP	1195 A > G (rs689466)
Niu [25]	2012	China	Asians	OSCC	TaqMan assay	+837 T > C (rs5275)

Note. OSCC: oral squamous cell carcinoma; OPL: oral precancerous lesions; PCR-RFLP: restriction fragment length polymorphism.