Prognostic Significance of the Tumor-Stroma Ratio in Epithelial Ovarian Cancer

Table 4

Univariate and multivariate survival analysis of the prognostic factors for progression-free and overall survival in 838 EOC patients.

Variable	Cases ()	TR cases ()	TD cases ()	Progression-free survival (PFS)					Overall survival (OS)
				Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
				Median of PFS		HR	95% CI for HR		Median of OS		HR	95% CI for HR
Age (year)					0.260	NA	NA	NA		0.061	NA	NA	NA
≤55	347	316	251	40					58
>55	491	434	359	31					48
Menopausal status					0.564	NA	NA	NA		0.076	NA	NA	NA
Yes	505	449	380	32					49
No	333	301	230	39					58
Histology					0.576	NA	NA	NA		0.123	NA	NA	NA
Serous	599	533	422	35					54
Mucous and others	239	217	188	37					53
Differentiation					0.001	1.142	0.979–1.333	0.092		0.060	NA	NA	NA
	420	368	311	40					59
	418	382	299	32					50
FIGO stage (2009)					<0.001	0.773	0.657–0.908	0.002		0.001	0.710	0.612–0.824	<0.001
I-II	243	210	155	42					58
III-IV	595	540	455	30					49
LN metastasis					0.020	0.869	0.732–1.031	0.108		<0.001	0.774	0.659–0.911	0.002
No	657	572	451	37					57
Yes	181	178	159	32					48
Residual disease					0.764	NA	NA	NA		0.716	NA	NA	NA
<1 cm	631	561	451	36					55
≥1 cm	207	189	159	34					50
Ascites volume (mL)					0.047	0.929	0.785–1.100	0.393		0.002	0.922	0.778–1.092	0.345
≤1000	591	525	414	36					55
>1000	247	225	196	34					51
Serum CA125 (U/mL)					0.154	NA	NA	NA		0.010	1.149	0.984–1.341	0.079
≤675	521	458	359	35					55
>675	317	292	251	35					52
STR					<0.001	0.731	0.615–0.827	<0.001		0.001	1.172	0.983–1.396	0.076
Stroma-poor	575	493	381	39					58
Stroma-rich	263	257	229	29					50

TR: tumor recurrence; TD: tumor-related death; LN: lymph node; : value, log rank test; HR: hazard ratio; CI: confidence interval; : value, Cox regression; NA: not applicable.