Attenuating Tumour Angiogenesis: A Preventive Role of Metformin against Breast Cancer

Figure 2

In vivo assessment of metformin treatment on tumour growth. Metformin (20 mg/kg body weight; Metformin group) or sterile PBS (Control group) was injected locally to mice with breast carcinoma for 15 consecutive days. (a) Average tumour size and (b) body weight were monitored and plotted against time for Metformin (closed circle) and Control group (open circle). Total changes of tumour volume (c) and body weight (d) were also presented as area under curve (AUC). Data are presented as means ± SD, -5.

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