Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells

<div>Vitamin D3 inhibited transforming growth factor-<i>β</i>1- (TGF-<i>β</i>1-) induced mesothelial cell (MC) cytoskeleton redistribution<i> in vitro</i>. MCs were cultured with TGF-<i>β</i>1 with or without addition of 1<i>α</i>,25(OH)<sub>2</sub>D<sub>3</sub> (vit. D). MC cytoskeletons were stained with anti-F-actin antibodies. In normal culture medium, the actin cytoskeleton (green) was in the cortical band and TGF-<i>β</i>1 promoted cytoskeleton redistribution (fibroblast-like cytoskeleton). Vitamin D inhibited TGF-<i>β</i>1-induced cytoskeleton redistribution. Nuclei were stained with DAPI (blue). Magnification ×400.</div>

BioMed Research International

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Figure 7

Figure 7: Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells 

Figure 7 | Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells 