Review Article
Recent Advances in Molecular Magnetic Resonance Imaging of Liver Fibrosis
Table 1
Studies that have assessed molecular MRI of liver fibrosis.
| Study/year | Targeted molecules | Targeting probes | Animal model | MR effect | Significance |
| Polasek et al., 2012 [40] | Type I collagen | EP-3533 | The rat DEN model & the CCl4 mouse model | Shortening the T1 relaxation time | Identifies fibrotic tissue in animal models of liver fibrosis | Fuchs et al., 2013 [41] | Type I collagen | EP-3533 | The CCl4 mouse model | Shortening the T1 relaxation time | Diagnoses and stage sliver fibrosis in an animal model | Chow et al., 2013 [42] | Fibrin-fibronectin | CLT1-peptide-targeted nanoglobular contrast agent (CLT1(Gd-DOTA)) | The CCl4 mouse model | Shortening the T1 relaxation time | Detected and stage sliver fibrosis by probing the accumulation of fibronectin | Ehling et al., 2013 [43] | Elastin | ESMA | The CCl4 mouse model | Shortening the T1 relaxation time | Elastin-based molecular MRI may be suitable for noninvasive monitoring of ECM remodeling during liver fibrosis | Wang et al., 2011 [44] | -Integrin | c(RGDyC)-USPIO | The CCl4 mouse model | Shortening the T2 relaxation time | Targets HSC imaging with c(RGDyC)-USPIO |
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