Animal Models of Depression and Drug Delivery with Food as an Effective Dosing Method: Evidences from Studies with Celecoxib and Dicholine Succinate

Figure 3

Effects of dosing with imipramine via food pellets on floating scores and other behaviours. (a) In comparison with control group, mice that received imipramine in food pellets over four weeks showed an increase of latency to float and total duration of floating in the forced swim test. No significant differences between the groups were found in parameters of anxiety (b) in the dark-light box and (c) O-maze tests. (d) Control and imipramine-treated mice showed similar numbers of rearings in the novel cage, distance travelled, and mean velocity in the open field test. (e) In the two-bottle sucrose preference test, water intake, sucrose solution intake, and sucrose preference were not different between imipramine-treated and control groups. , versus control (unpaired -test). Con: control group ; Imi-food: imipramine-treated group . All data are means ± SEM.

(a) Forced swim test

(b) Dark-light box

(c) O-maze

(d) Locomotory tests

(e) Sucrose test