Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells

Figure 1

LPA effects on cell proliferation of Hela cells. (a) Hela cells were treated with different doses and time of LPA; MTT essay was performed. LPA significantly stimulated the proliferation of Hela cells in a dose-dependent and time-dependent manner. (b) Effect of inhibitors on LPA stimulation of cell proliferation. Hela cells were treated with LPA at 20 μM plus different inhibitors for different time periods before MTT essay. PD98059 (MAPK inhibitor, at 10 μM), PD98059 (MAPK inhibitor, at 10 μM), and Y-27632 (Rho inhibitor, at 10 μM) were applied, respectively. MAPK inhibitor, PD98059, significantly blocked the stimulation effect of LPA on cell proliferation in Hela cells. PI3K inhibitor, LY294002, partially blocked the LPA effect on cell proliferation.

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