Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice

Figure 2

Immunofluorescent analysis of SR-BI localization in aorta of Tie2-Scarb1 × Scarb1-KO and Scarb1-KO mice. Mouse aorta sections were stained for SR-BI (a and d, red) and CD31 (b and e, green). Colocalization of SR-BI and CD31 was presented on (c) and (f). Blue = DAPI. (a, b, and c) Immunohistological analysis of SR-BI localization in aortic sections of Tie2-Scarb1 × Scarb1-KO mice. Colocalization of SR-BI and CD31 was found in aortic endothelial cells. In several EC stained for SR-B1 red color was present on both apical and basolateral sides (a). (d, e, and f) Immunohistological analysis of SR-BI localization in aortic sections of Scarb1-KO mice. There is no red signal in aorta from Scarb1-KO mice.

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