Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice

Figure 8

Effect of EC specific overexpression of Scarb1 on atherosclerosis. Percent of aortic lesions, as determined by en face analysis, is shown (a) for Tie2-Scarb1 transgenic females () versus C57Bl/6N control females () on HFHC diet for 6 months (), (b) for 8-month-old Tie2-Scarb1 × ApoE-KO mice () versus nontransgenic sibling controls () on normal chow diet (), and (c) for Tie2-Scarb1 × Scarb1-KO mice () versus nontransgenic sibling Scarb1-KO controls () on HFHC diet for 3 months ().

(a)

(b)

(c)