Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice
Table 1
Plasma lipid profiles of Tie2-Scarb1 transgenic females on normal C57Bl/6N, Scarb1-KO, or apoE-KO backgrounds. All animals were kept on normal chow diet.
Genotype
TC
TG
PL
FC
CE
HDL-C
Normal C57Bl/6N background
Tie2-Scarb1, = 35–39
85 ± 2
66 ±
174 ± 4
20 ± 1
65 ± 2
45 ±
Sibling control, = 13
86 ± 3
79 ± 3
178 ± 7
22 ± 1
63 ± 2
61 ± 3
ApoE-KO background
Tie2-Scarb1, = 28–33
463 ± 17
131 ± 21
260 ± 7
127 ± 4
346 ± 12
N/A
Sibling control, = 9–11
455 ± 24
160 ± 42
240 ± 9
124 ± 9
333 ± 21
N/A
Scarb1-KO background
Tie2-Scarb1, = 15–19
232 ± 8
101 ± 6
316 ± 8
108 ± 7
124 ± 10
132 ± 6
Sibling control, = 9–12
221 ± 7
105 ± 5
310 ± 14
104 ± 5
118 ± 9
103 ± 16
All values are expressed in units of mg/dL. ; . TC: total cholesterol; TG: triglycerides; PL: phospholipids; FC: free cholesterol; CE: cholesteryl ester.
