State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews

Table 2

Bivariate and multivariable analysis for review quality, effect estimates, and scholarly citations.

Dependent variable	Independent variable(s)	Bivariate analysis^*			Multivariable analysis^†
		Coefficient	Standard error		Coefficient	Standard error
AMSTAR score	Year of publication	0.27	0.11	0.022	0.21	0.11	0.052
	BMSC therapy	1.58	0.57	0.009	1.36	0.56	0.021
Change in LVEF (%)	BMSC therapy	1.41	0.42	0.002	—	—	—
Yearly Web of Science citations	Journal impact factor	0.85	0.20	<0.001	0.56	0.20	0.007
	Authors	0.10	0.04	0.034	—	—	—
	Corresponding author from North America or Europe	1.32	0.33	<0.001	0.77	0.32	0.022
	Studies included	0.04	0.02	0.037	—	—	—
	Patients included (100 people)	0.07	0.03	0.030	—	—	—
	RCTs only	−1.35	0.56	0.023	−0.90	0.43	0.046

Only independent variables significantly () associated with the dependent variable of interest are reported, but all the following variables were tested: year of publication, authors, North American/European corresponding author, studies included, patients included, RCTs only, type of setting, BMSC therapy, patient-level design, random effects analysis, small study effect testing, subgroup analysis, metaregression, conflict of interests, and funding; ^†a multivariable linear regression model with backward stepwise selection ( for exit 0.10) was used, including in the model all variables significantly () associated with the dependent variable at bivariate analysis; A Measurement Tool to Assess Systematic Reviews (AMSTAR) score; BMSC = bone marrow-derived stem cell; LVEF = left ventricular ejection fraction; RCT = randomized clinical trial.